Sleep Tied to Objective and Subjective Cognition

Amy Costa Poor objective sleep efficiency may contribute to older adults overestimating their cognitive abilities, preliminary findings from a pilot study of objective and subjective cognitive measures have shown. The pilot study underscored the important role of objective sleep measures to better understand discrepancies when patients’ own reports of everyday cognitive function don’t align with … Read more

FDA Panel Rejects Pimavanserin for Alzheimer’s Psychosis

A US Food and Drug Administration (FDA) advisory panel has rejected the atypical antipsychotic pimavanserin (Nuplazid, Acadia Pharmaceuticals) for the treatment of Alzheimer’s disease psychosis (ADP). In a 9-3 vote, the Psychopharmacologic Drugs Advisory Committee (PDAC) found that the drug’s manufacturer failed to offer convincing evidence of its efficacy in patients with ADP. Today’s rejection … Read more

Opioid Use in the Elderly a Dementia Risk Factor?

Opioid use in the elderly is associated with an almost 40% increased risk of dementia, in new findings that suggest exposure to these drugs may be another modifiable risk factor for dementia. “Clinicians and others may want to consider that opioid exposure in those aged 75-80 increases dementia risk, and to balance the potential benefits … Read more

Long COVID Neuropsychiatric Deficits Greater Than Expected

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. NEW ORLEANS – Patients experiencing brain fog and other persistent symptoms of long COVID show significant deficits on neuropsychiatric testing that correspond to infection with prior acute COVID-19, adding to mounting evidence of the significant toll the chronic condition can have … Read more

New Data Support Electroconvulsive Therapy for Depression

Advocates and users of electroconvulsive therapy (ECT) have received further scientific backing: a retrospective cohort study has provided further evidence that ECT can prevent suicide among severely depressed patients. The patient cohort comprised 27,231 men and 40,096 women who had been treated as inpatients. The average age was 45.1 years (range: 18-103 years), and 4982 … Read more

Neuropsychiatric Risks of COVID: New Data

The neuropsychiatric ramifications of severe COVID-19 infection appear to be no different than for other severe acute respiratory infections (SARI). Results of a large study showed risks of new neuropsychiatric illness were significantly and similarly in adults surviving either severe COVID-19 infection or other SARI, compared with the general population. This suggests that disease severity, … Read more

TBI Linked to ‘Striking’ Risk for CVD, Endocrine, Brain Disorders

Mild traumatic brain injury (TBI) is linked to a significantly increased risk for a host of subsequent cardiovascular, endocrine, neurologic, and psychiatric disorders, new research shows. Incident of hypertension, coronary heart disease, diabetes, stroke, depression, and dementia all began to increase soon after the brain injury and persisted over a decade in both mild and … Read more

Impaired Vision an Overlooked Dementia Risk Factor

Impaired vision in older adults is an underrecognized and modifiable dementia risk factor, new research suggests. Investigators analyzed estimated population attributable fractions (PAFs) associated with dementia in more than 16,000 older adults. A PAF represents the number of dementia cases that could be prevented if a given risk factor were eliminated. Results showed the PAF … Read more

Virtual Reality an ‘Exciting Opportunity’ for Geriatric Psychiatry

Researchers are reality turning their attention to virtual VR for the treatment of psychiatric disorders in older adults. Recent studies have highlighted the usefulness of VR in treating depression and loneliness in older patients who may be socially isolated because of their age, comorbidities, or the COVID-19 pandemic. Dr Harmehr Sekhon “The unique capability of … Read more

Long-Term Cannabis Use Linked to Dementia Risk Factors

Long-term cannabis use is linked to hippocampal atrophy and poorer cognitive function in midlife — known risk factors for dementia. A large prospective, longitudinal study showed long-term cannabis users had an intelligence quotient (IQ) decline from age 18 to midlife (mean 5.5 IQ points), poorer learning and processing speed compared to childhood, and self-reported memory … Read more