Novel Drug ‘Promising’ for Concomitant Depression, Insomnia

The novel antidepressant seltorexant (Janssen Pharmaceuticals) may be beneficial for patients with concomitant major depressive disorder (MDD) and sleep disturbance, new research suggests. In a randomized, placebo-controlled, adaptive dose-finding study conducted in more than 200 patients with MDD, those with more severe insomnia at baseline had a greater improvement in depressive symptoms vs those with … Read more

Antipsychotic Safe, Effective for Resistant Depression

Cariprazine (Vraylar) is a safe and effective adjunctive treatment for adults with major depressive disorder (MDD) who have an inadequate response to antidepressant monotherapy, new results from a phase 3 study show. Already approved by the US Food and Drug Administration (FDA) to treat adults with schizophrenia and manic, mixed, or depressive episodes of bipolar … Read more

A Novel Target in Schizophrenia?

AUT00206, a novel compound that targets potassium channels in brain interneurons, not only improves gamma oscillations in patients with schizophrenia, it also improves their symptoms, new randomized trial data suggest. In a randomized, double-blind study that included two dozen men with schizophrenia, AUT00206 compared with placebo increased the power of gamma oscillations, which were in … Read more

Sublingual Dexmedetomidine May Rapidly Calm Bipolar Agitation

An investigational, orally dissolving formulation film of dexmedetomidine (BXCL501, BioXcel Therapeutics) can rapidly relieve mild to moderate acute agitation in patients with bipolar disorder (BD), new research suggests. The phase 3 SERENITY II trial included almost 400 adults with bipolar I or II disorder and acute agitation. Results showed relief from acute agitation kicked in … Read more

High Praise, Condemnation for CMS Aduhelm Coverage Plan

Medicare has received a key endorsement of its plan to restrict payment for the controversial Alzheimer’s disease (AD) drug aducanumab (Aduhelm) — but also drew pleas from other groups for more generous reimbursement of the drug, as well as expected similar medications currently in development . The Centers for Medicare & Medicaid Services (CMS) received … Read more