MRI Plus Deep Learning Models Estimate Brain-Aging

The covered study in this summary was published in bioRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Using the Layer-wise Relevance Propagation algorithm and various structural MRI modalities (T1-weighted, fluid-attenuated inversion recovery [FLAIR]and susceptibility-weighted magnitude images [SWI]), brain age can be estimated. The structural abnormalities found were changes in the … Read more

Unique Primary Care Model Effective for Comorbid Depression, PTSD

A unique primary care program successfully manages patients with depression and comorbid posttraumatic stress disorder (PTSD) and, if widely implemented may result in more rapid treatment and help alleviate wait times for specialty psychiatric care. Zachary Zuschlag, MD “We know there are strains on the mental healthcare system, and sometimes something as simple as getting … Read more

Death Risk Spikes With New Onset-Depression After RA Diagnosis

The development of depression after a rheumatoid arthritis diagnosis increased the risk for death “more than sixfold” when compared with having no depression at diagnosis, according to Danish researchers. Cumulative mortality at 10 years was approximately 37% in patients with comorbid RA and depression versus around 13.5% of RA patients with no depression, Jens Kristian … Read more

ECT Tied to Reduction in All-Cause Mortality in Major Depression

Electroconvulsive therapy (ECT) may lower mortality for patients with treatment-resistant major depressive disorder (MDD), new research suggests. In an analysis of data from a large database of inpatients across the United States, use of ECT for those with resistant MDD was associated with significantly lower in-hospital mortality compared with those who did not receive ECT. … Read more

Specialties Differ on Value, Utilization of Telehealth: Study

Attitudes toward the use of telehealth differ markedly among mental health, primary care, and specialty care clinicians, according to a study published June 7 in JAMA Network Open. The study involved eight clinics of the Department of Veterans Affairs (VA) New England Healthcare System. Mental health professionals used telehealth — including phone and video visits … Read more

FDA Denies Petition to Disqualify Researchers Over Controversial Ketamine Studies

The US Food and Drug Administration (FDA) has declined to take further action against a group of investigators at Hennepin County Medical Center/Hennepin Healthcare (HCMC), who conducted controversial studies involving ketamine and other sedatives in agitated persons without their consent. A citizen filed by Public Citizen, a consumer advocacy group, had asked the FDA to … Read more

Mechanical Touch Therapy Device Promising for Anxiety

An at-home investigational device is a promising noninvasive therapeutic approach for anxiety disorders, results from an open-label pilot trial suggest. The small study showed users of the Mechanical Affective Touch Therapy (MATT) had improved anxiety and depression symptoms, which corresponded to positive changes in alpha and theta oscillatory activity. Dr Linda Carpenter “MATT is part … Read more

ADHD Genetic Risk Probed as Biomarker for Alzheimer

The study covered in this summary was published in medrxiv.org as a preprint and has not yet been peer-reviewed. Key Takeaways Elderly patients with a high attention deficit hyperactivity disorder polygenic risk score but no clinical ADHD diagnosis are at elevated risk for progressive longitudinal cognitive deterioration. Cognitive decline was most common in people with … Read more

‘Fragmented’ Speech Patterns May Predict Psychosis Relapse

Patients with first-episode psychosis (FEP) show altered speech patterns and content that could pinpoint symptom severity — and help predict future relapse, two new studies suggest. In the first study, an algorithm was created to analyze speech patterns and semantic content to create novel “speech networks.” Compared with their healthy peers, patients with FEP had … Read more

A Novel Target in Schizophrenia?

AUT00206, a novel compound that targets potassium channels in brain interneurons, not only improves gamma oscillations in patients with schizophrenia, it also improves their symptoms, new randomized trial data suggest. In a randomized, double-blind study that included two dozen men with schizophrenia, AUT00206 compared with placebo increased the power of gamma oscillations, which were in … Read more