Acupuncture Eases Anxiety in Parkinson’s Patients

Acupuncture is an effective treatment for anxiety in patients with Parkinson’s disease (PD), results of a randomized controlled trial show. Both sham and real acupuncture eased PD-related anxiety at the end of 8-week treatment, but only real acupuncture had an enduring effect at 2 months after treatment ended. The early effect with sham acupuncture in … Read more

Baseline Neuromotor Abnormalities Persist in Schizophrenia

Baseline dyskinesia and neurological soft signs (NSS) predicted the disease process of schizophrenia over a 21-year follow-up period, based on data from 243 adult patients. Neuromotor abnormalities in psychotic disorders have long been ignored as side effects of antipsychotic drugs, but they are gaining new attention as a component of the disease process, with implications … Read more

Mortality Advantage With Pimavanserin in Parkinson’s Psychosis?

Pimavanserin may convey a mortality advantage over other treatments for older adults with Parkinson’s disease (PD) psychosis, new research suggests. In a real-world analysis of more than 21,000 patients with PD psychosis, treatment with pimavanserin was associated with significantly lower mortality compared with off-label use of atypical antipsychotics. However, this was only found during the … Read more

The Role of Transcranial Magnetic Stimulation in Major Depressive Disorder

This transcript has been edited for clarity. Madhukar Trivedi, MD: Hello. Welcome to the podcast. My name is Madhukar Trivedi. I’m professor of psychiatry at UT Southwestern and the founding director of the Center for Depression Research and Clinical Care. Today it gives me great pleasure to introduce my colleague and friend, Dr Jonathan Downar, … Read more

DBS Helpful for Motor Function but Not Depression in Parkinson’s

Treatment with deep brain stimulation improved motor function and quality of life, but depression scores increased after 1 year, based on data from 20 adults. Subthalamic nucleus deep brain stimulation (STN-DBS) has emerged as an effective treatment for Parkinson’s disease symptoms, with evidence supporting improved motor symptoms and quality of life, wrote Francesca Mameli, PsyD, … Read more

Restless Legs Syndrome Common in X-linked Adrenoleukodystrophy

Restless legs syndrome occurred in approximately 40% of adults with X-linked adrenoleukodystrophy, based on data from 32 individuals. Dr John Winkelman Patients with X-linked adrenoleukodystrophy (ALD), a neurodegenerative disease, often experience gait and balance problems, as well as leg discomfort, sleep disturbances, and pain, wrote John W. Winkelman, MD, of Massachusetts General Hospital, Boston, and … Read more

New Guidance on Palliative Care for Neurologic Disorders

The American Academy of Neurology (AAN) has released new expert guidance on palliative care for patients with stroke, dementia, Parkinson’s disease, and other neurologic disorders. Palliative care includes much more than hospice services, lead author of the new position statement Lynne P. Taylor, MD, University of Washington, Seattle, and a fellow of the AAN, said … Read more

Resting-State EEG Differentiates Depression in Parkinson’s

The covered study in this summary was published on as a preprint and has not yet been peer reviewed. Key Takeaways A machine-learning algorithm demonstrated efficacy in accurately distinguishing patients with Parkinson’s disease (PD) who had depression from patients with PD without depression and controls with depression. This information lends insight into cortical of … Read more