Primary Care Moves Patients With Addiction to Self-Advocacy

Samuel Werner, DO, a family medicine physician in West Hartford, Connecticut, vividly remembers one patient who was struggling with a drug addiction. The man was having trouble holding down a steady job because of his dependence, but with Werner’s guidance, he started on buprenorphine. Werner also connected him with a social worker to address housing … Read more

Novel Smartphone App Helps Reduce Fear of Cancer Recurrence

A novel “smartphone psychotherapy” application has been shown to relieve some of the anxiety and fear about cancer recurrence (FCR) that often causes distress to cancer survivors. The intervention is comprised of smartphone problem-solving therapy and behavioral activation apps, and was tested in a study that involved 447 survivors of breast cancer. The results showed … Read more

Single Dose of Psilocybin for Major Depression Tied to Short-Term Remission

A single 25 mg dose of synthetic psilocybin in combination with psychotherapy appears to effectively ease symptoms of treatment-resistant depression (TRD) — at least in the short-term, new research shows. In the largest study of psilocybin for TRD to-date, results of the phase 2b randomized, double-blind trial show participants in the 25-mg dose group experienced … Read more

‘Amazing’ Phase 3 Results for Novel Schizophrenia Combo Drug

VIENNA — The investigational agent xanomeline-trospium (KarXT, Karuna Therapeutics) achieves significant and clinically meaningful improvements in schizophrenia symptom scores without causing problematic adverse effects, new research suggests. Results from the phase 3 EMERGENT-2 trial, which included more than 250 patients with schizophrenia, showed that those who received xanomeline-trospium for 5 weeks achieved a significant reduction … Read more

Antibiotic May Enhance TMS, Improve Depression Outcomes

Administering D-cycloserine (DCS) along with transmagnetic stimulation (TMS) may be a promising strategy to improve outcomes in major depressive disorder (MDD), new research suggests. “The take-home message is that this proof-of-concept study opens up a new avenue of treatment research so that in the future, we may be able to provide our patients with safe … Read more

Home-Based Transcranial Stimulation Succeeds for Major Depression

Home-based transcranial direct current stimulation with real-time supervision significantly improved clinical symptoms of major depressive disorder, based on data from 26 individuals. Major depressive disorder (MDD) remains a leading cause of disability and a significant predictor of suicide worldwide, Rachel D. Woodham, PhD, of the University of East London and colleagues wrote. Transcranial direct current … Read more

Canadian Doctors Call for Mental Health Funding

The Ontario Medical Association (OMA) and Primary Care Collaborative have called for $37.5 million in immediate funding, as well as $75 million annually for 10 years, to help primary care providers treat patients with depression, anxiety, and addiction. The recommendation is part of a four-point plan to strengthen mental health and addiction services in primary … Read more

Money Matters in Psychiatric Assessment

Despite money’s central role in our lives, many trainees — and some seasoned practitioners — skirt around financial issues. Some clinicians confess that inquiring about patients’ finances feels “too personal.” They fear that asking about money could suggest that the clinician is primarily concerned with getting paid. Some clinicians feel that looking into patients’ finances … Read more

Suicide Notes Are ‘Unique Window’ Into Motives, Risks in the Elderly

Suicide notes left by elderly people provide a unique opportunity to better understand and prevent suicide in this often vulnerable population. A new analysis of notes penned by seniors who died by suicide reveals several common themes. These include feeling as if they were a burden, feelings of guilt, experiencing mental illness, loneliness, or isolation, … Read more

MDD Tied to Childhood Trauma Is Treatable

Despite a higher symptom burden, patients with major depressive disorder (MDD) and a history of childhood trauma (CT) can achieve significant recovery following treatment with a combination of pharmacotherapy and psychotherapy, new research suggests. Results from a meta-analysis of 29 studies from 1966 to 2019, which included almost 7000 adults with MDD, showed that more … Read more