Best Meds for Insomnia Identified?

Two drugs have emerged as the optimal medications for treating insomnia based on the “best-available evidence,” but there are caveats. In a comprehensive comparative-effectiveness analysis, lemborexant and eszopiclone showed the best efficacy, acceptability, and tolerability for acute and long-term insomnia treatment. However, eszopiclone may cause substantial side effects — and safety data on lemborexant were … Read more

Electroacupuncture Promising for Depression-Related Insomnia

Electroacupuncture (EA) may significantly improve sleep quality in patients with depression who also have insomnia, new research suggests. In a study of more than 200 adults with depression and comorbid insomnia, change from baseline to week 8 on the Pittsburgh Sleep Quality Index (PSQI) was 3 points greater in the group receiving EA vs a … Read more

Sleep a Potential Treatment Target for Schizophrenia?

A new analysis reveals a bidirectional relationship between sleep patterns and schizophrenia, leading researchers to suggest that sleep may be a potential treatment target for the disorder. Applying a Mendelian randomization (MR) approach, the investigators selected genetic variants from a meta-analysis of genome-wide association studies (GWAS) conducted using data from UK Biobank and 23andMe. They … Read more

Sleep Tied to Objective and Subjective Cognition

Amy Costa Poor objective sleep efficiency may contribute to older adults overestimating their cognitive abilities, preliminary findings from a pilot study of objective and subjective cognitive measures have shown. The pilot study underscored the important role of objective sleep measures to better understand discrepancies when patients’ own reports of everyday cognitive function don’t align with … Read more

Long-term Erratic Sleep May Predict Later-Life Cognitive Problems

CHARLOTTE, NC — Erratic sleep patterns over years or even decades, along with a patient’s age and history of depression, may be harbingers of cognitive impairment later in life, an analysis of decades of data from a large sleep study has found. “What we were a little surprised to find in this model was that … Read more

Growing Up in Unsafe Neighborhoods Tied to Poor Sleep in Adults

Growing up in neighborhoods perceived as unsafe is linked to disordered sleep in adulthood, in new findings that suggest improving neighborhood safety can have long-term benefits on sleep quality. “Our study expands upon previous findings by demonstrating a possible link between neighborhood environments in childhood and sleep health during adulthood,” lead author Symielle Gaston, PhD, … Read more

Sleep a Neglected Pillar of Health, National Survey Shows

Physicians and patients agree on the importance of sleep for health, yet a few clinicians obtain a patient sleep history, and a few patients discuss their sleep problems with healthcare providers, a new national survey shows. “Everybody thinks that sleep should be a pillar of health, but there is a big communication gap between patients … Read more

Has the Anti-Benzodiazepine Backlash Gone Too Far?

When benzodiazepines were first introduced, they were greeted with enthusiasm. Librium came first, in 1960, followed by Valium in 1962, and they were seen as an improvement over barbiturates for the treatment of anxiety, insomnia, and seizures. From 1968 to 1982, Valium (diazepam) was the No. 1-selling US pharmaceutical: 2.3 billion tablets of Valium were … Read more

The Importance of Treating Insomnia in Psychiatric Illness

Insomnia rates continue to rise in the setting of the pandemic,1 Contributing to increasing rates of depression and anxiety, as well as worsening symptoms of other severe mental illnesses. Data suggests this symptom, defined as chronic sleep onset and/or sleep continuity problems associated with impaired daytime functioning, is common in psychiatric illnesses, and can worsen … Read more

Restless Legs Syndrome Surged Early During COVID Pandemic

Individuals with restless legs syndrome showed an increase in symptom severity in the early phase of the COVID-19 pandemic in the United States in 2020, but this increase had waned by 2021, according to data from 500 participants in the National Restless Legs Syndrome Opioid Registry . Sufferers of restless legs syndrome (RLS) experience not … Read more